[HTML][HTML] Mammalian patatin domain containing proteins: a family with diverse lipolytic activities involved in multiple biological functions
PC Kienesberger, M Oberer, A Lass, R Zechner - Journal of lipid research, 2009 - ASBMB
The human genome expresses nine patatin-like phospholipase domain containing proteins
(PNPLA1–9). Members of this family share a protein domain discovered initially in patatin,
the most abundant protein of the potato tuber. Patatin is a lipid hydrolase with an unusual
folding topology that differs from classical lipases. Mammalian PNPLAs include lipid
hydrolases with specificities for diverse substrates such as triacylglycerols, phospholipids,
and retinol esters. Analysis of induced mutant mouse models and the clinical phenotype of …
(PNPLA1–9). Members of this family share a protein domain discovered initially in patatin,
the most abundant protein of the potato tuber. Patatin is a lipid hydrolase with an unusual
folding topology that differs from classical lipases. Mammalian PNPLAs include lipid
hydrolases with specificities for diverse substrates such as triacylglycerols, phospholipids,
and retinol esters. Analysis of induced mutant mouse models and the clinical phenotype of …
