Endospanins regulate a postinternalization step of the leptin receptor endocytic pathway
K Séron, C Couturier, S Belouzard, J Bacart… - Journal of Biological …, 2011 - ASBMB
Endospanin-1 is a negative regulator of the cell surface expression of leptin receptor (OB-R),
and endospanin-2 is a homologue of unknown function. We investigated the mechanism for
endospanin-1 action in regulating OB-R cell surface expression. Here we show that
endospanin-1 and-2 are small integral membrane proteins that localize in endosomes and
the trans-Golgi network. Antibody uptake experiments showed that both endospanins are
transported to the plasma membrane and then internalized into early endosomes but do not …
and endospanin-2 is a homologue of unknown function. We investigated the mechanism for
endospanin-1 action in regulating OB-R cell surface expression. Here we show that
endospanin-1 and-2 are small integral membrane proteins that localize in endosomes and
the trans-Golgi network. Antibody uptake experiments showed that both endospanins are
transported to the plasma membrane and then internalized into early endosomes but do not …
